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Molecular assays for antimalarial drug resistance surveillance

Molecular assays for antimalarial drug resistance surveillance: A objective product profile.

Antimalarial drug resistance is a major constraint for malaria administration and elimination efforts. Artemisinin-based combination treatment is now the mainstay for malaria remedy. Nonetheless, delayed parasite clearance following remedy with artemisinin derivatives has now unfold inside the Higher Mekong Sub space and can emerge or unfold to totally different malaria endemic areas. This unfold is of good concern for malaria administration programmes, as no choices to artemisinin-based combination therapies are anticipated to be obtainable inside the near future.
  • There is a must strengthen surveillance packages for early detection and response to the antimalarial drug resistance threat. Current surveillance is principally executed by therapeutic efficacy analysis; nonetheless these analysis are sophisticated and every time- and resource-intensive.
  • For quite a lot of frequent antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated to antimalarial drug resistance present a straightforward and extremely efficient instrument to look at the emergence and unfold of resistant parasites.
  • Fully totally different strategies to analyse molecular markers associated to antimalarial drug resistance will be discovered, each with advantages and drawbacks. Nonetheless, procedures are often not adequately harmonized to facilitate comparisons between web sites.
  • Proper right here we describe the objective product profiles for checks to analyse molecular markers associated to antimalarial drug resistance, give attention to how use of current strategies could also be standardised, and decide the requirements for an excellent product that may allow malaria endemic nations to provide useful spatial and temporal information on the unfold of resistance.
mygentaur.com
mygentaur.com

NATtrol T.vaginalis Verification Panel (17 x 0.7 mL)

NATTVGP-C 17 x 0.7 mL
EUR 722

NATtrol Respiratory Verification Panel (20 x 0.25mL)

NATRVP-QIA 20 x 0.25mL
EUR 927.36
Description: Please contact Gentaur in order to receive the datasheet of the product.

SeroDetect HTLV Ab Verification Panel (5 X 1.5 mL)

KZMC011 5 X 1.5 mL
EUR 334.56
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol MTB Verification Panel (5 x 0.6mL, 6 x 1.6mL)

NATMTBP-C 5 x 0.6mL, 6 x 1.6mL
EUR 613

HIV 1/2 Rapid Test Verification Panel (10 X 0.25 mL)

KZMC029 10 X 0.25 mL
EUR 183

SeroDetect HIV-Ab Verification Panel (5 X 1.5 mL)

KZMC006 5 X 1.5 mL
EUR 286

NATtrol Influenza/RSV Verification Panel (21 x 0.5mL)

NATFRVP-C 21 x 0.5mL
EUR 862

Influenza Rapid Test Verification Panel (20 X 0.5 mL)

KZMC021 20 X 0.5 mL
EUR 286

SeroDetect Anti-HBs Verification Panel (6 X 1.5 mL)

KZMC008 6 X 1.5 mL
EUR 286

SeroDetect Anti-HCV Verification Panel (5 X 1.5 mL)

KZMC010 5 X 1.5 mL
EUR 286

NATtrol Respiratory Verification Panel (RVP) (20 X 0.6 mL)

NATRVP-IDI 20 X 0.6 mL
EUR 943

NATtrol Respiratory Verification Panel 2 (23 x 0.6mL) (Ea)

NATRVP2-BIO 23 x 0.6mL
EUR 1165.73
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Respiratory Verification Panel 2.1 (24 x 0.6mL) (EA)

NATRVP2.1-BIO 24 x 0.6mL
EUR 1133

SeroDetect Dengue Fever Verification Panel (9 X 0.5 mL)

KZMC028 10 X 0.5 mL
EUR 277

NATtrol Zika Virus Range Verification Panel (4 x 0.5 mL)

NATZIKV-RV 4 x 0.5 mL
EUR 599

NATtrol Respiratory Verification Panel 2 (21 x 0.25mL) (EA)

NATRVP2-QIA 21 x 0.25mL
EUR 925

SeroDetect Anti-HBcore Verification Panel (5 X 1.5 mL)

KZMC009 5 X 1.5 mL
EUR 334.56
Description: Please contact Gentaur in order to receive the datasheet of the product.

SeroDetect HIV-Ab Range Verification Panel (10 X 1.5 mL)

KZMC024 10 X 1.5 mL
EUR 286

SeroDetect West Nile Virus Verification Panel (10 X 0.5 mL)

KZMC027 10 X 0.5 mL
EUR 334.56
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Respiratory Verification Panel (15 x 0.5mL; 2 x 1mL)

NATRVP-NNS 15 x 0.5mL; 2 x 1mL
EUR 784

NATtrol Clostridium difficile Verification Panel (6 X 1 mL)

NATCDIVP-C 6 X 1 mL
EUR 586

NATtrol Zika Virus (PRVABC59) Range Verification Panel (4 x 0.5 mL)

NATZIKV(PRV)-RV 4 x 0.5 mL
EUR 599

SeroDetect HCV-Ab Mixed Titer Verification Panel I (15 X 0.25 mL)

KZMC022 15 X 0.25 mL
EUR 269

SeroDetect HIV-1/ HIV-2 Ag/Ab Combo Verification Panel (5 X 1.25mL)

KZMC030 5 X 1.25mL
EUR 328

ICP-MS Initial Calibration Verification Standard 1

CL-ICV-1 125ML
EUR 487.2

Core Panel Multi-Tumor control slides, set of 5

TS900 Set of 5
EUR 145
Description: Core Panel Multi-Tumor control slides, set of 5

Core Panel Multi-Tumor control slides, set of 25

TS900-25 Set of 25
EUR 425
Description: Core Panel Multi-Tumor control slides, set of 25

Breast Panel Multi-Tumor control slides, set of 5

TS901 Set of 5
EUR 145
Description: Breast Panel Multi-Tumor control slides, set of 5

Breast Panel Multi-Tumor control slides, set of 25

TS901-25 Set of 25
EUR 395
Description: Breast Panel Multi-Tumor control slides, set of 25

Goat IgG (-ve control for flow cytometry) (isotype control)

20011-100 100 test
EUR 123.6

BSA Control for Age-BSA

2221-BSA each
EUR 210

BSA Control for AGE-BSA

35R-AA007 10 mg
EUR 268.8
Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007

Flow Control Fitting for Flypad

FLY1254 EACH
EUR 101.84

Control for ER, 4 cases (1.5mm)

ERC081 1
EUR 102
Description: IHC control array containing 4 breast cancer cases of strong, moderate, weak/nil estrogen receptor (ER) expressers in duplicates

Control for PR, 3 cases (1.5mm)

PRC061 1
EUR 102
Description: IHC control array containing 3 breast cancer cases of strong, moderate, low/negative progesterone receptor (PR) expressers in duplicates

Flow Control Fitting for Blowgun

FLY1252 EACH
EUR 80.95

Deer IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20024-2 100 ug
EUR 270

Control for DOG1, 3 cases (1.5mm)

DOG1061 1
EUR 102
Description: IHC control array containing 3 GIST cases of strong, moderate, weak/nil DOG1 expressers in duplicates

Control for HER2, 4 cases (1.5mm)

HRC081 1
EUR 102
Description: IHC control array containing 4 breast cancer cases of strong, moderate, low and negative HER2 breast cancer expressers in duplicates

Control for Ckit, 6 samples (1.5mm)

CKIT061 1
EUR 102
Description: Gastrointestinal stroma tumors, 6 cores, 3 cases in duplicates showing strong, moderate and no expression of cKit molecule.

SLLK, Control Peptide for TSP1 Inhibitor

HY-P0301 1mg
EUR 159.6

Control/Blocking peptide for Human WNT5a

WNT511-P 100 ug
EUR 196.8

Rec. Human CD21 protein control for WB

CD21-C 100 ul
EUR 343.2

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-100 100 Slides
EUR 847.2

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-25 25 Slides
EUR 278.4

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-5 5 Slides
EUR 117.6

Thiostatin Rat protein, control for western

TSTN11-C 100 ul
EUR 343.2

Mouse IgG (-ve control for flow cytometry)

20008-1-100 100 tests
EUR 123.6

Rabbit IgG (-ve control for flow cytometry)

20009-1-100 100 tests
EUR 123.6

Control Sections for FD NeuroSilver™ Kit

PCS101 each
EUR 69.6

Purified, Human S100 protein control for WB

S1002-C 100 ul
EUR 343.2

Control/Blocking peptide for Human WNT-1

WNT111-P 100 ug
EUR 548.4

Negative Control Antibody for Mouse Monoclonals

V8785-100UG 100ug
EUR 349.3
Description: To serve as a true negative control for various procedures, this monoclonal IgG should be used under the identical conditions and at the same dilution as the rabbit monoclonal antibody being used for a positive reaction.

Negative Control Antibody for Mouse Monoclonals

V8785-20UG 20ug
EUR 153.3
Description: To serve as a true negative control for various procedures, this monoclonal IgG should be used under the identical conditions and at the same dilution as the rabbit monoclonal antibody being used for a positive reaction.

Negative Control Antibody for Mouse Monoclonals

V8785SAF-100UG 100ug
EUR 349.3
Description: To serve as a true negative control for various procedures, this monoclonal IgG should be used under the identical conditions and at the same dilution as the rabbit monoclonal antibody being used for a positive reaction.

SLLK, Control Peptide for TSP1 Inhibitor(TFA)

HY-P0301A 5mg
EUR 456

Purified, Bovine S100 protein control for WB

S1001-C 100 ul
EUR 343.2

Positive Control for Anti-Rat MEH Antibody

MEHCON 100 uL
EUR 150

Human Pancreatic Amylase protein control for Western blot

PAMY13-C 100 ul
EUR 343.2

Human Apolipoprotein B protein control for WB

APOB21-C 100 ul
EUR 343.2

Positive Control for Anti-Rat CYP2C Antibody

P2CCON 100 uL
EUR 150

Positive Control for Anti-Rat CYP2D Antibody

P2DCON 100 uL
EUR 150

Positive Control for Anti-Rat CYP2B1 Antibody

P2B1PTCON 100 uL
EUR 150

Positive Control for Anti-Rat CYP3A2 Antibody

P3A2PTCON 100 uL
EUR 150

Haptoglobin Human Plasma protein control for WB

HGLB18-C 100 ul
EUR 343.2

Control/Blocking peptide for Mouse Vimentin (Vim)

VIM11-C 100 ug
EUR 196.8

Mouse IgG Isotype control (purified) validated for

NG903 7 ml
EUR 195
Description: Mouse IgG Isotype control (purified) validated for IHC; Ready-To-Use

Mouse IgG Isotype control (purified) validated for

NG903C 1 ml
EUR 275
Description: Mouse IgG Isotype control (purified) validated for IHC; Concentrate; Minimum 1:50 dilution

Mouse IgM Isotype control (purified) validated for

NG906 7 ml
EUR 265
Description: Mouse IgM Isotype control (purified) validated for IHC; Ready-To-Use

Mouse IgM Isotype control (purified) validated for

NG906C 1 ml
EUR 295
Description: Mouse IgM Isotype control (purified) validated for IHC; Concentrate

Positive Control for Anti-Human CYP3A Antibody

P3ACON 100 uL
EUR 150

Eppendorf Centrifuge 5430R Knob Control Refrigerated- IVD Only

E5428000465 EACH
EUR 8115.6

Control/Blocking peptide for Ephrin-B2 antibody

NIVE2B-C 100 ug
EUR 196.8

Positive Control for Anti-Human CYP1B1 Antibody

PH1B1CON 100 uL
EUR 150

Positive Control for Anti-Human CYP2E1 Antibody

P2E1PTCON 100 uL
EUR 150

Positive Control for Anti-Human CYP1A2 Antibody

P1A2CON 100 uL
EUR 150

Chicken Egg Ovalbumin protein control for Western

OVA11-C 100 ul
EUR 343.2

Rat Ceruloplasmin protein control for western blot

CP17-C 100 ul
EUR 343.2

Positive control tissue section for each individua

Control-slides- Set of 5
EUR 119
Description: Positive control tissue section for each individual antibody; Based on availability; INQUIRE

Positive control tissue section for each individua

Control-Slides-for-each-antibody Set of 25
EUR 355
Description: Positive control tissue section for each individual antibody; Based on availability; INQUIRE

Control sections for FD NeuroApop™ Kit (frozen)

PCS102- each
EUR 87.6

Control sections for FD NeuroApop™ Kit (frozen)

PCS102-2 each
EUR 80.54
Description: Best quality products

Mouse Ceruloplasmin protein control for western blot

CP16-C 100 ul
EUR 343.2

Purified Flagellin (salmonella) protein control for WB

FLGN17-C 100 ul
EUR 343.2

Human Hemopexin purified protein control for Western

HPEX11-C 100 ul
EUR 343.2

Hemopexin Mouse, purified protein control for Western

HPEX16-C 100 ul
EUR 343.2

Q-VE-OPh (Negative Control for Q-VD-OPh)

GW8990-1 1
EUR 228.1

Human Apolipoprotein C-I protein control for WB

APOC11-C 100 ul
EUR 343.2

Control sections for FD NeuroApop™ Kit (paraffin)

PCS102-1 each
EUR 80.44
Description: Best quality products

Purified Human Survivin protein for WB +ve control

SURV11-C 100 ul
EUR 343.2

Human Apolipoprotein C-II protein control for WB

APOC22-C 100 ul
EUR 343.2

Monkey (Rhesus) Serum Albumin protein control for WB

ALBMK21-C 100 ul
EUR 343.2

Monkey (Rhesus) Serum Albumin protein control for WB

ALBMK22-C 100 ul
EUR 343.2

Positive Control for Anti-Rat CHP2B1/2 Antibody

P2B12PTCON 100 uL
EUR 150

Bovine Adenosine deaminase protein control for Western

ADA11-C 100 ul
EUR 343.2

Positive Control for anti-GST p-forms: rat P

GSTCON3 100 uL
EUR 150

 

New Mammalian Objective of Rapamycin (mTOR) Modulators Derived from Pure Product Databases and Marine Extracts by Using Molecular Docking Strategies.

Mammalian objective of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that capabilities as a grasp regulator of cellular improvement and metabolism, in response to nutrient and hormonal stimuli.

mTOR capabilities in two distinct complexes-mTORC1 is delicate to rapamycin, whereas, mTORC2 is insensitive to this drug. Deregulation of mTOR’s enzymatic train has roles in most cancers, weight issues, and ageing.

Rapamycin and its chemical derivatives are the solely medication that inhibit the hyperactivity of mTOR, nonetheless fairly a number of undesirable uncomfortable side effects have been described on account of its therapeutic use.

The goal of this analysis was to find out new compounds of pure origin that will end in medication with fewer undesirable uncomfortable side effects. Now now we have used computational strategies (molecular docking and calculated ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) parameters) which have enabled the selection of candidate compounds, derived from marine pure merchandise, SuperNatural II, and ZINC pure merchandise, for inhibitors concentrating on, every, the ATP and the rapamycin binding web sites of mTOR. Now now we have confirmed experimental proof of the inhibitory train of 11 chosen compounds in opposition to mTOR.

Now now we have moreover discovered the inhibitory train of a model new marine extract in opposition to this enzyme. The outcomes have been talked about regarding the necessity to find out new molecules for therapeutic use, significantly in opposition to ageing, and with fewer undesirable uncomfortable side effects.

Molecular cloning and expression analysis of three ThERFs involved inside the response to waterlogging stress of Taxodium ‘Zhongshanshan406’, and subcellular localization of the gene merchandise.

As a subfamily of the APETALA 2/ethylene response issue binding protein (AP2/EREBP) transcription concern superfamily, the ethylene response concern (ERF) is broadly involved inside the regulation of improvement and response to different abiotic stresses in vegetation, and has been confirmed to be the precept transcription concern regulating transcription of the genes related to hypoxia and waterlogging stress.
  • On this analysis, three ThERF genes, with very important variations in expression profile in response to flooding stress, had been acknowledged from the transcriptomics info acquired from Taxodium hybrid ‘Zhongshanshan 406’ (T. mucronatum Tenore × T. distichum (L.) Rich) beneath waterlogging stress: ThERF15, ThERF39 and ThRAP2.3 (GenBank ID: KY463467, KY463468 and KY463470, respectively).
  • The entire-length cDNA of each of the three ERFs was obtained using the RACE (quick amplification cDNA ends) methodology, and all three had been intron-free. Numerous protein sequence alignments indicated that ThERF15, ThERF39 and ThRAP2.Three proteins all had only one AP2-ERF space and belonged to the ERF subfamily.
  • A transient gene expression assay demonstrated that ThERF15, ThERF39 and ThRAP2.Three had been all localized to the nucleus. Precise-time quantitative PCR (qPCR) revealed that the expression of ThERF15, ThERF39 and ThRAP2.Three exhibited very important variations, in distinction with the administration, in response to 2 ranges of flooding remedy (half-flooding or total-submergence) of ‘Zhongshanshan 406’.
  • Quantification of ethylene focus revealed that ethylene was further associated to the extent of expression than the interval of flooding remedy. Based mostly totally on the experimental outcomes above, ThERF15, ThERF39 and ThRAP2.Three had been acknowledged as being related to the regulation of downstream flooding- responsive gene expression in ‘Zhongshanshan 406’. ThRAP2.Three is nearly actually to be a key downstream-response ERF gene to reply the output of the ethylene signal generated by flooding stress

ProtoGlow ECL 200ml Kit

NAT1010 EACH
EUR 354

ProtoGlow ECL 500ml Kit

NAT1012 EACH
EUR 627.6

100G Acrylamide

NAT1014 100G
EUR 120

500G Acrylamide

NAT1016 500G
EUR 261.6

1KG Acrylamide

NAT1018 1KG
EUR 412.8

25G AquaPor LE

NAT1020 25G
EUR 132

100G AquaPor LE GTAC

NAT1022 100G
EUR 250.8

500G AquaPor LE GTAC

NAT1024 500G
EUR 878.4

25G AquaPor ES

NAT1026 25G
EUR 152.4

100G AquaPor ES

NAT1028 100G
EUR 350.4

25G AquaPor LM

NAT1030 25G
EUR 288

100G AquaPor LM

NAT1032 100G
EUR 860.4

25G AquaPor HR

NAT1034 25G
EUR 236.4

100G AquaPor HR

NAT1036 100G
EUR 592.8

25G AquaPor 3:1

NAT1038 25G
EUR 250.8

100G AquaPor 3:1

NAT1040 100G
EUR 570

25G Bis (Methylene Bis-Acrylamide)

NAT1042 25G
EUR 100.8

25G DATD Ultrapure

NAT1044 25G
EUR 168

250G Glycine

NAT1046 250G
EUR 94.8

1KG Glycine Ultrapure

NAT1048 1KG
EUR 128.4

250G Tris

NAT1050 250G
EUR 102

1KG Tris Ultrapure

NAT1052 1KG
EUR 177.6

100G Tricine

NAT1054 100G
EUR 120

100G Ion Exchange Resin (mixed bed)

NAT1056 100G
EUR 96

25G Riboflavin

NAT1058 25G
EUR 96

25ML TEMED

NAT1060 25ML
EUR 99.6

25G Ammonium Persulfate

NAT1062 25G
EUR 96

100G Ammonium Persulfate

NAT1064 100G
EUR 118.8

1G Dithiothreitol (DTT)

NAT1066 1G
EUR 103.2

5G Dithiothreitol (DTT)

NAT1068 5G
EUR 183.6

50ML 2-Mercaptoethanol

NAT1070 50ML
EUR 112.8

100G SDS Ultrapure

NAT1072 100G
EUR 111.6

1KG SDS Ultrapure

NAT1074 1KG
EUR 457.2

250G Urea

NAT1076 250G
EUR 98.4

1KG Urea

NAT1078 1KG
EUR 138

450ML Glycerol Ultrapure

NAT1080 450ML
EUR 132

200ML Tween 20 Ultrapure

NAT1082 200ML
EUR 132

1L Tween 20

NAT1084 1L
EUR 169.2

200ML Formamide

NAT1086 200ML
EUR 111.6

500ML Boric Acid

NAT1088 500ML
EUR 103.2

100G EDTA

NAT1090 100G
EUR 94.8

500G EDTA

NAT1092 500G
EUR 177.6

GelDry Film 11 X 12 cm

NAT1094 PK50
EUR 100.8

25ML Formamide CE

NAT1096 25ML Ask for price

25ML Glass Bond

NAT1098 25ML
EUR 158.4

450ML Glass Free

NAT1100 450ML
EUR 196.8

GelDry Film 22.5 X 22.5 cm

NAT1102 PK50
EUR 130.8

1L DEPC Treated Water

NAT1104 1L
EUR 120

Sterling Rapid Silver Stain Kit

NAT1106 1KIT
EUR 265.2

1L ProtoBlue Safe

NAT1108 1L
EUR 159.6

4L ProtoBlue Safe

NAT1110 4L
EUR 282

1L ProtoStain Blue

NAT1112 1L
EUR 164.4

25ML Nuclistain

NAT1114 25ML
EUR 128.4

450ML AcrylaGel 30%

NAT1116 450ML
EUR 128.4

1L AcrylaGel 30%

NAT1118 1L
EUR 177.6

450ML Bis-AcrylaGel 2%

NAT1120 450ML
EUR 98.4

1L Bis-AcrylaGel 2%

NAT1122 1L
EUR 111.6

450ML UreaGel 29:1 Concentrate

NAT1124 450ML
EUR 133.2

1L UreaGel 29:1 Concentrate

NAT1126 1L
EUR 183.6

UreaGel 29:1 System 1L Kit

NAT1128 EACH
EUR 171.6

UreaGel 29:1 System 2.2L Kit

NAT1130 EACH
EUR 253.2

450ML SequaGel UreaGel Concentrate

NAT1132 450ML
EUR 126

1L SequaGel UreaGel Concentrate

NAT1134 1L
EUR 160.8

SequaGel Sequencing System 1L Kit

NAT1136 1KIT
EUR 171.6

SequaGel Sequencing System 2.2L Kit

NAT1138 EACH
EUR 253.2

100ML SequaGel Buffer

NAT1140 100ML
EUR 80.4

200ML SequaGel UreaGel Buffer

NAT1142 200ML
EUR 84

450ML SequaGel UreaGel-6

NAT1144 450ML
EUR 115.2

1L SequaGel UreaGel-6

NAT1146 1L
EUR 151.2

450ML SequaGel UreaGel-8

NAT1148 450ML
EUR 115.2

1L SequaGel UreaGel-8

NAT1150 1L
EUR 151.2

450ML SequaGel UreaGel Diluent

NAT1152 450ML
EUR 90

1L SequaGel UreaGel Diluent

NAT1154 1L
EUR 103.2

90ML SequaGel Complete Buffer

NAT1156 90ML
EUR 79.2

200ML SequaGel UreaGel Complete Buffer

NAT1158 200ML
EUR 85.2

450ML SequaGel XR

NAT1160 450ML
EUR 126

1L SequaGel XR

NAT1162 1L
EUR 165.6

100ML SequaGel XR Concentrate

NAT1164 100ML
EUR 128.4

450ML SequaGel XR Concentrate

NAT1166 450ML
EUR 361.2

200ML SequaGel MD Monomer Solution

NAT1168 200ML
EUR 220.8

SequaGel MD SSCP Kit

NAT1170 1KIT
EUR 253.2

SequaGel MD Heteroduplex Kit

NAT1172 EACH
EUR 265.2

1.2ML SequaGel MD SSCP Stop Solution

NAT1174 1.2ML
EUR 85.2

450ML AccuGel 19:1 (30%)

NAT1176 450ML
EUR 126

1L AccuGel 19:1 (30%)

NAT1178 1L
EUR 165.6

450ML AccuGel 19:1 (40%)

NAT1180 450ML
EUR 130.8

1L AccuGel 19:1 (40%)

NAT1182 1L
EUR 168

450ML AccuGel 29:1 (30%)

NAT1184 450ML
EUR 126

1L AccuGel 29:1 (30%)

NAT1186 1L
EUR 165.6