Amyloid

Amyloid Beta Protein

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Fundamental description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present inside the vascular amyloid deposits. Aβ40 accommodates of C-terminal membrane insertion space. It reveals structural transition from random coil to a α-helical building in a water-micelle medium.

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that occur inside the hippocampus, neocortex, and amygdala of victims with Alzheimer′s sickness.
Amyloid β Protein Fragment 1-40 (Aβ40) varieties cation primarily based ion channels.

Utility

Amyloid β Protein Fragment 1-40 has been used:

  • inside the temperature primarily based conformational analysis using Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) analysis
  • as a reference commonplace in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of victims with head trauma
  • as a ingredient of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts
amyloid
amyloid

Reconstitution

For maximal natural train, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Totally different Notes

Lyophilized from 0.1% TFA in H2O

Abstract

Alzheimer’s sickness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For just a few years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology inside the human thoughts and the diploma of scientific dementia. Present advances in our understanding of the occasion of amyloid pathology have helped treatment this thriller. Substantial proof now signifies that the solubility of Aβ, and the quantity of Aβ in quite a few swimming swimming pools, may be further rigorously related to sickness state. The composition of these swimming swimming pools of Aβ shows utterly totally different populations of amyloid deposits, and has explicit correlates with the scientific standing of the affected particular person. Imaging utilized sciences, along with new amyloid imaging brokers based mostly totally on the chemical building of histologic dyes, in the intervening time are making it doable to hint amyloid pathology along with sickness growth inside the residing affected particular person. Curiously, these approaches level out that the Aβ deposited in AD is totally totally different from that current in animal fashions. Principally, deposited Aβ is further merely cleared from the thoughts in animal fashions, and does not current the equivalent bodily and biochemical traits as a result of the amyloid current in AD. This raises needed factors regarding the occasion and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

Amyloid Beta Protein

SPR-485H 1 mg
EUR 435
Description: Human Synthetic Amyloid Beta Peptide 1-42 (HFIP treated)

Amyloid Beta Protein

SPR-487B 100 µg
EUR 382
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-487C 100 µg x2
EUR 611
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-487E 100 µg x5
EUR 1240
Description: Human Synthetic Amyloid Beta 1-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-488B 100 µg
EUR 617
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-488C 100 µg x2
EUR 988
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-488E 100 µg x5
EUR 1998
Description: Human Synthetic Amyloid Beta 1-42 Oligomers

Amyloid Beta Protein

SPR-492B 100 µg
EUR 432

Amyloid Beta Protein

SPR-492C 100 µg x2
EUR 691
Description: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Amyloid Beta Protein

SPR-492E 100 µg x5
EUR 1405
Description: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

Amyloid beta A4 protein

AP78722 1mg
EUR 2640

Amyloid beta A4 protein

AP79877 1mg
EUR 2640

Amyloid beta A4 protein

AP80103 1mg
EUR 2640

Amyloid beta A4 protein

AP80119 1mg
EUR 2640

Amyloid beta A4 protein

AP80183 1mg
EUR 2640

Amyloid beta A4 protein

AP80191 1mg
EUR 2640

Amyloid beta Protein (20-29)

20-abx266170
  • EUR 526.80
  • EUR 861.60
  • EUR 393.60
  • 10 mg
  • 25 mg
  • 5 mg

Amyloid beta Protein (33-42)

20-abx266417
  • EUR 644.40
  • EUR 1078.80
  • EUR 460.80
  • 10 mg
  • 25 mg
  • 5 mg

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