mygentaur.com

Molecular assays for antimalarial drug resistance surveillance

Molecular assays for antimalarial drug resistance surveillance: A goal product profile.

Antimalarial drug resistance is a significant constraint for malaria administration and elimination efforts. Artemisinin-based mixture therapy is now the mainstay for malaria treatment. Nonetheless, delayed parasite clearance following treatment with artemisinin derivatives has now unfold contained in the Greater Mekong Sub area and might emerge or unfold to completely completely different malaria endemic areas. This unfold is of good concern for malaria administration programmes, as no decisions to artemisinin-based mixture therapies are anticipated to be obtainable contained in the close to future.
  • There’s a should strengthen surveillance packages for early detection and response to the antimalarial drug resistance menace. Present surveillance is principally executed by therapeutic efficacy evaluation; nonetheless these evaluation are refined and each time- and resource-intensive.
  • For numerous frequent antimalarials, parasite drug resistance has been correlated with particular genetic mutations, and the molecular markers related to antimalarial drug resistance current an easy and intensely environment friendly instrument to have a look at the emergence and unfold of resistant parasites.
  • Totally completely completely different methods to analyse molecular markers related to antimalarial drug resistance shall be found, every with benefits and disadvantages. Nonetheless, procedures are sometimes not adequately harmonized to facilitate comparisons between websites.
  • Correct proper right here we describe the target product profiles for checks to analyse molecular markers related to antimalarial drug resistance, give consideration to how use of present methods is also standardised, and resolve the necessities for a wonderful product that will permit malaria endemic nations to offer helpful spatial and temporal info on the unfold of resistance.
mygentaur.com
mygentaur.com

Breast Panel Multi-Tumor control slides

TS901 Set of 5
EUR 218

Breast Panel Multi-Tumor control slides

TS901-25 Set of 25
EUR 485

Goat IgG (-ve control for flow cytometry) (isotype control)

20011-100 100 test
EUR 103

BSA Control for Age-BSA

2221-BSA
EUR 175

BSA Control for AGE-BSA

35R-AA007 10 mg
EUR 224
Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007

Control for DOG1, 3 cases (1.5mm)

DOG1061 1
EUR 85
Description: IHC control array containing 3 GIST cases of strong, moderate, weak/nil DOG1 expressers in duplicates

Control for Ckit, 6 samples (1.5mm)

CKIT061 1
EUR 85
Description: Gastrointestinal stroma tumors, 6 cores, 3 cases in duplicates showing strong, moderate and no expression of cKit molecule.

Control for HER2, 4 cases (1.5mm)

HRC081 1
EUR 85
Description: IHC control array containing 4 breast cancer cases of strong, moderate, low and negative HER2 breast cancer expressers in duplicates

SLLK, Control Peptide for TSP1 Inhibitor

HY-P0301 1mg
EUR 133

Control for ER, 4 cases (1.5mm)

ERC081 1
EUR 85
Description: IHC control array containing 4 breast cancer cases of strong, moderate, weak/nil estrogen receptor (ER) expressers in duplicates

Control for PR, 3 cases (1.5mm)

PRC061 1
EUR 85
Description: IHC control array containing 3 breast cancer cases of strong, moderate, low/negative progesterone receptor (PR) expressers in duplicates

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-100 100 Slides
EUR 706

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-25 25 Slides
EUR 232

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-5 5 Slides
EUR 98

Thiostatin Rat protein, control for western

TSTN11-C 100 ul
EUR 286

Control/Blocking peptide for Human WNT5a

WNT511-P 100 ug
EUR 164

Ferret IgG (Control, non-immune, isotype control), semi-pure for ELISA

20021-1 100 ug
EUR 225

Elk IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20024-1 100 ug
EUR 225

Deer IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20024-2 100 ug
EUR 225

Bison IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20025-1 100 ug
EUR 225

Raccoon IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20026-1 100 ug
EUR 225

Skunk IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20027-1 100 ug
EUR 225

Recombinant (E.coli) Respiratory Syncytial Virus fusion (RSV-F) protein control for western blot

RSV11-C 100 ul
EUR 286

Holder for Plasmid Midi, Maxi and Maxi plus, Ion Exchange column

FAPDE-holder-for-ion-exchange 1 prep
EUR 158

Mouse IgG (-ve control for flow cytometry)

20008-1-100 100 tests
EUR 103

Rabbit IgG (-ve control for flow cytometry)

20009-1-100 100 tests
EUR 103

Human Apolipoprotein B protein control for WB

APOB21-C 100 ul
EUR 286

Rec. Human CD21 protein control for WB

CD21-C 100 ul
EUR 286

Bovine Adenosine deaminase protein control for Western

ADA11-C 100 ul
EUR 286

Mouse Ceruloplasmin protein control for western blot

CP16-C 100 ul
EUR 286

Rat Ceruloplasmin protein control for western blot

CP17-C 100 ul
EUR 286

Haptoglobin Human Plasma protein control for WB

HGLB18-C 100 ul
EUR 286

Human Hemopexin purified protein control for Western

HPEX11-C 100 ul
EUR 286

Hemopexin Mouse, purified protein control for Western

HPEX16-C 100 ul
EUR 286

SLLK, Control Peptide for TSP1 Inhibitor(TFA)

HY-P0301A 5mg
EUR 380

Purified Flagellin (salmonella) protein control for WB

FLGN17-C 100 ul
EUR 286

Positive Control for Anti-Rat CYP3A2 Antibody

P3A2PTCON 100 uL
EUR 125

Positive Control for Anti-Human CYP3A Antibody

P3ACON 100 uL
EUR 125

Positive Control for Anti-Human CYP1A2 Antibody

P1A2CON 100 uL
EUR 125

Positive Control for Anti-Rat CYP2B1 Antibody

P2B1PTCON 100 uL
EUR 125

Positive Control for Anti-Rat CYP2C Antibody

P2CCON 100 uL
EUR 125

Positive Control for Anti-Rat CYP2D Antibody

P2DCON 100 uL
EUR 125

Positive Control for Anti-Human CYP2E1 Antibody

P2E1PTCON 100 uL
EUR 125

Purified bovine Lactoferrin protein control for Western

LTF13-C 100 ul
EUR 286

Mouse negative control sera (purified) for IHC

NCM802M 7 ml
EUR 199

Control/Blocking peptide for Ephrin-B2 antibody

NIVE2B-C 100 ug
EUR 164

Chicken Egg Ovalbumin protein control for Western

OVA11-C 100 ul
EUR 286

Positive Control for Anti-Rat MEH Antibody

MEHCON 100 uL
EUR 125

Control Sections for FD NeuroSilver™ Kit

PCS101 each
EUR 53.83
Description: Best quality products

Positive Control for Anti-Human CYP1B1 Antibody

PH1B1CON 100 uL
EUR 125

Purified, Bovine S100 protein control for WB

S1001-C 100 ul
EUR 286

Purified, Human S100 protein control for WB

S1002-C 100 ul
EUR 286

Control/Blocking peptide for Mouse Vimentin (Vim)

VIM11-C 100 ug
EUR 164

Control/Blocking peptide for Human WNT-1

WNT111-P 100 ug
EUR 457

Control siRNA Vector (pGB-control)

9500C-20
EUR 338

Mouse Anti-Cardiolipin Ig's -ve control for ELISA

5502 1 ml
EUR 225

Human Apolipoprotein C-I protein control for WB

APOC11-C 100 ul
EUR 286

Human Apolipoprotein C-II protein control for WB

APOC22-C 100 ul
EUR 286

Human Apolipoprotein C-III protein control for WB

APOC32-C 100 ul
EUR 286

Human plasma Apolipoprotein E protein control for WB

APOE13-C 100 ul
EUR 286

Human Plasma Apolipoprotein J protein control for WB

APOJ13-C 100 ul
EUR 286

Purified Cholera Toxin protein control for Western Blot

CTOX11-C 100 ul
EUR 286

Chicken Egg Conalbumin (ovotransferrin) protein control for Western

CECA15-C 100 ul
EUR 286

Chicken Egg white proteins total control for Western

CEGW12-C 100 ul
EUR 286

Purified human Catalase (CATL) protein control for WB

CATL11-C 100 ul
EUR 286

Positive Control for Anti-Human Cytochrome b5 Antibody

Cb5CON 100 uL
EUR 125

Chicken Egg yellow proteins total control for Western

CEYP12-C 100 ul
EUR 286

Rabbit Beta Actin (muscle) protein control for Western

ACTB15-C 100 ul
EUR 324

Recombinant Beta Lactamase protein control for Western blot

BLAC11-C 100 ul
EUR 286

Chicken Serum Albumin protein control for Western blot

ALBC15-C 100 ul
EUR 286

Monkey (Rhesus) Serum Albumin protein control for WB

ALBMK21-C 100 ul
EUR 286

Monkey (Rhesus) Serum Albumin protein control for WB

ALBMK22-C 100 ul
EUR 286

Chicken Ovomucoid (trypsin inhibitor) protein control for Western

COVM13-C 100 ul
EUR 286

Control/Blocking peptide for Mouse Histone deacetylase 1

HDAC111-P 100 ug
EUR 164

Purified Human Neutrophil Elastase protein control for WB

ESTE11-C 100 ul
EUR 286

Positive Control for Anti-Rat CYP1A1/1A2 Antibody

P1ACON 100 uL
EUR 125

Positive Control for Anti-Rat CHP2B1/2 Antibody

P2B12PTCON 100 uL
EUR 125

Purified Lassa fever Nucleoprotein control for Western Blotting

LFNP15-C-10 100 ul
EUR 286

Purified Nipah virus Glycoprotein control for Western Blotting

NIV11-C 100 ul
EUR 286

Purified Nipah virus Nucleoprotein control for Western Blotting

NIV21-C 100 ul
EUR 225

Myoglobin, Human Cardiac, purified protein control for western

MYG17-C 100 ul
EUR 286

Human Prothrombin (Factor II) protein control for Western

PRTN11-C 100 ul
EUR 286

Mouse Prothrombin (Factor II) protein control for Western

PRTN13-C 100 ul
EUR 286

Control sections for FD NeuroApop™ Kit (paraffin)

PCS102-1 each
EUR 67.03
Description: Best quality products

Control sections for FD NeuroApop™ Kit (frozen)

PCS102-2 each
EUR 67.12
Description: Best quality products

Human Pancreatic Amylase protein control for Western blot

PAMY13-C 100 ul
EUR 286

Human Salivary Amylase protein positive control for WB

SAMY16-C 100 ul
EUR 286

Purified Human Survivin protein for WB +ve control

SURV11-C 100 ul
EUR 286

Purified, recombinant Human TACE control protein for WB

TACE11-C 100 ul
EUR 286

Control sections for FD NeuroApop™ Kit (frozen)

PCS102- each
EUR 73

Recombinant Porcine reproductive and Respiratory syndrome virus 1 nuclear protein (PRRSV1-NP) control for western blot

PRSNP11-C 100 ul
EUR 286

Recombinant Porcine reproductive and Respiratory syndrome virus 2 nuclear protein (PRRSV2 NP) control for western blot

PRSNP21-C 100 ul
EUR 286

Recombinant Porcine reproductive and Respiratory syndrome virus 1 nonstructural protein (PRRSV1-NSP) control for western blot

PRSNSP11-C 100 ul
EUR 286

Recombinant Porcine reproductive and Respiratory syndrome virus 2 nonstructural protein (PRRSV2-NSP) control for western blot

PRSNSP22-C 100 ul
EUR 286

Quality Control

abx098966-1vial 1 vial
EUR 300
  • Shipped within 5-7 working days.

pMD18- Control

PVT10563 2 ug
EUR 266

 

New Mammalian Goal of Rapamycin (mTOR) Modulators Derived from Pure Product Databases and Marine Extracts by Utilizing Molecular Docking Methods.

Mammalian goal of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that capabilities as a grasp regulator of mobile enchancment and metabolism, in response to nutrient and hormonal stimuli.

mTOR capabilities in two distinct complexes-mTORC1 is delicate to rapamycin, whereas, mTORC2 is insensitive to this drug. Deregulation of mTOR’s enzymatic prepare has roles in most cancers, weight points, and ageing.

Rapamycin and its chemical derivatives are the solely remedy that inhibit the hyperactivity of mTOR, nonetheless pretty quite a few undesirable uncomfortable unwanted side effects have been described on account of its therapeutic use.

The purpose of this evaluation was to search out out new compounds of pure origin that can finish in remedy with fewer undesirable uncomfortable unwanted side effects. Now now we have now used computational methods (molecular docking and calculated ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) parameters) which have enabled the choice of candidate compounds, derived from marine pure merchandise, SuperNatural II, and ZINC pure merchandise, for inhibitors concentrating on, each, the ATP and the rapamycin binding websites of mTOR. Now now we have now confirmed experimental proof of the inhibitory prepare of 11 chosen compounds in opposition to mTOR.

Now now we have now furthermore found the inhibitory prepare of a mannequin new marine extract in opposition to this enzyme. The outcomes have been talked about concerning the need to search out out new molecules for therapeutic use, considerably in opposition to ageing, and with fewer undesirable uncomfortable unwanted side effects.

Molecular cloning and expression evaluation of three ThERFs concerned contained in the response to waterlogging stress of Taxodium ‘Zhongshanshan406’, and subcellular localization of the gene merchandise.

As a subfamily of the APETALA 2/ethylene response problem binding protein (AP2/EREBP) transcription concern superfamily, the ethylene response concern (ERF) is broadly concerned contained in the regulation of enchancment and response to completely different abiotic stresses in vegetation, and has been confirmed to be the principle transcription concern regulating transcription of the genes associated to hypoxia and waterlogging stress.
  • On this evaluation, three ThERF genes, with crucial variations in expression profile in response to flooding stress, had been acknowledged from the transcriptomics data acquired from Taxodium hybrid ‘Zhongshanshan 406’ (T. mucronatum Tenore × T. distichum (L.) Wealthy) beneath waterlogging stress: ThERF15, ThERF39 and ThRAP2.3 (GenBank ID: KY463467, KY463468 and KY463470, respectively).
  • Your complete-length cDNA of every of the three ERFs was obtained utilizing the RACE (fast amplification cDNA ends) methodology, and all three had been intron-free. Quite a few protein sequence alignments indicated that ThERF15, ThERF39 and ThRAP2.Three proteins all had just one AP2-ERF area and belonged to the ERF subfamily.
  • A transient gene expression assay demonstrated that ThERF15, ThERF39 and ThRAP2.Three had been all localized to the nucleus. Exact-time quantitative PCR (qPCR) revealed that the expression of ThERF15, ThERF39 and ThRAP2.Three exhibited crucial variations, in distinction with the administration, in response to 2 ranges of flooding treatment (half-flooding or total-submergence) of ‘Zhongshanshan 406’.
  • Quantification of ethylene focus revealed that ethylene was additional related to the extent of expression than the interval of flooding treatment. Primarily based completely on the experimental outcomes above, ThERF15, ThERF39 and ThRAP2.Three had been acknowledged as being associated to the regulation of downstream flooding- responsive gene expression in ‘Zhongshanshan 406’. ThRAP2.Three is sort of really to be a key downstream-response ERF gene to answer the output of the ethylene sign generated by flooding stress
Product not found

Leave a Comment

Your email address will not be published. Required fields are marked *