Molecular assays for antimalarial drug resistance surveillance: A goal product profile.
Antimalarial drug resistance is a significant constraint for malaria administration and elimination efforts. Artemisinin-based mixture therapy is now the mainstay for malaria treatment. Nonetheless, delayed parasite clearance following treatment with artemisinin derivatives has now unfold contained in the Greater Mekong Sub area and might emerge or unfold to completely completely different malaria endemic areas. This unfold is of good concern for malaria administration programmes, as no decisions to artemisinin-based mixture therapies are anticipated to be obtainable contained in the close to future.
- There’s a should strengthen surveillance packages for early detection and response to the antimalarial drug resistance menace. Present surveillance is principally executed by therapeutic efficacy evaluation; nonetheless these evaluation are refined and each time- and resource-intensive.
- For numerous frequent antimalarials, parasite drug resistance has been correlated with particular genetic mutations, and the molecular markers related to antimalarial drug resistance current an easy and intensely environment friendly instrument to have a look at the emergence and unfold of resistant parasites.
- Totally completely completely different methods to analyse molecular markers related to antimalarial drug resistance shall be found, every with benefits and disadvantages. Nonetheless, procedures are sometimes not adequately harmonized to facilitate comparisons between websites.
- Correct proper right here we describe the target product profiles for checks to analyse molecular markers related to antimalarial drug resistance, give consideration to how use of present methods is also standardised, and resolve the necessities for a wonderful product that will permit malaria endemic nations to offer helpful spatial and temporal info on the unfold of resistance.
 Breast Panel Multi-Tumor control slides |
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| TS901 | Innovex | Set of 5 | EUR 218 |
Breast Panel Multi-Tumor control slides |
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| TS901-25 | Innovex | Set of 25 | EUR 485 |
 (isotype control)) Goat IgG (-ve control for flow cytometry) (isotype control) |
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| 20011-100 | Alpha Diagnostics | 100 test | EUR 103 |
 BSA Control for Age-BSA |
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| 2221-BSA | Biovision | EUR 175 | |
 BSA Control for AGE-BSA |
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| 35R-AA007 | Fitzgerald | 10 mg | EUR 224 |
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Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007 |
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) Control for DOG1, 3 cases (1.5mm) |
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| DOG1061 | Pantomics | 1 | EUR 85 |
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Description: IHC control array containing 3 GIST cases of strong, moderate, weak/nil DOG1 expressers in duplicates |
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) Control for Ckit, 6 samples (1.5mm) |
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| CKIT061 | Pantomics | 1 | EUR 85 |
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Description: Gastrointestinal stroma tumors, 6 cores, 3 cases in duplicates showing strong, moderate and no expression of cKit molecule. |
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) Control for HER2, 4 cases (1.5mm) |
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| HRC081 | Pantomics | 1 | EUR 85 |
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Description: IHC control array containing 4 breast cancer cases of strong, moderate, low and negative HER2 breast cancer expressers in duplicates |
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 SLLK, Control Peptide for TSP1 Inhibitor |
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| HY-P0301 | MedChemExpress | 1mg | EUR 133 |
) Control for ER, 4 cases (1.5mm) |
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| ERC081 | Pantomics | 1 | EUR 85 |
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Description: IHC control array containing 4 breast cancer cases of strong, moderate, weak/nil estrogen receptor (ER) expressers in duplicates |
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) Control for PR, 3 cases (1.5mm) |
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| PRC061 | Pantomics | 1 | EUR 85 |
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Description: IHC control array containing 3 breast cancer cases of strong, moderate, low/negative progesterone receptor (PR) expressers in duplicates |
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) PAS/Glycogen, For Digestion (Control Slides) |
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| TCS0024-100 | ScyTek Laboratories | 100 Slides | EUR 706 |
PAS/Glycogen, For Digestion (Control Slides) |
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| TCS0024-25 | ScyTek Laboratories | 25 Slides | EUR 232 |
PAS/Glycogen, For Digestion (Control Slides) |
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| TCS0024-5 | ScyTek Laboratories | 5 Slides | EUR 98 |
 Thiostatin Rat protein, control for western |
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| TSTN11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Control/Blocking peptide for Human WNT5a |
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| WNT511-P | Alpha Diagnostics | 100 ug | EUR 164 |
, semi-pure for ELISA) Ferret IgG (Control, non-immune, isotype control), semi-pure for ELISA |
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| 20021-1 | Alpha Diagnostics | 100 ug | EUR 225 |
) Elk IgG, semi-pure for ELISA (Control, non-immune, isotype control) |
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| 20024-1 | Alpha Diagnostics | 100 ug | EUR 225 |
) Deer IgG, semi-pure for ELISA (Control, non-immune, isotype control) |
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| 20024-2 | Alpha Diagnostics | 100 ug | EUR 225 |
) Bison IgG, semi-pure for ELISA (Control, non-immune, isotype control) |
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| 20025-1 | Alpha Diagnostics | 100 ug | EUR 225 |
) Raccoon IgG, semi-pure for ELISA (Control, non-immune, isotype control) |
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| 20026-1 | Alpha Diagnostics | 100 ug | EUR 225 |
) Skunk IgG, semi-pure for ELISA (Control, non-immune, isotype control) |
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| 20027-1 | Alpha Diagnostics | 100 ug | EUR 225 |
 Respiratory Syncytial Virus fusion (RSV-F) protein control for western blot) Recombinant (E.coli) Respiratory Syncytial Virus fusion (RSV-F) protein control for western blot |
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| RSV11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Holder for Plasmid Midi, Maxi and Maxi plus, Ion Exchange column |
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| FAPDE-holder-for-ion-exchange | Favorgen | 1 prep | EUR 158 |
) Mouse IgG (-ve control for flow cytometry) |
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| 20008-1-100 | Alpha Diagnostics | 100 tests | EUR 103 |
) Rabbit IgG (-ve control for flow cytometry) |
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| 20009-1-100 | Alpha Diagnostics | 100 tests | EUR 103 |
 Human Apolipoprotein B protein control for WB |
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| APOB21-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Rec. Human CD21 protein control for WB |
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| CD21-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Bovine Adenosine deaminase protein control for Western |
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| ADA11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Mouse Ceruloplasmin protein control for western blot |
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| CP16-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Rat Ceruloplasmin protein control for western blot |
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| CP17-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Haptoglobin Human Plasma protein control for WB |
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| HGLB18-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human Hemopexin purified protein control for Western |
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| HPEX11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Hemopexin Mouse, purified protein control for Western |
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| HPEX16-C | Alpha Diagnostics | 100 ul | EUR 286 |
) SLLK, Control Peptide for TSP1 Inhibitor(TFA) |
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| HY-P0301A | MedChemExpress | 5mg | EUR 380 |
 protein control for WB) Purified Flagellin (salmonella) protein control for WB |
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| FLGN17-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Positive Control for Anti-Rat CYP3A2 Antibody |
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| P3A2PTCON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Human CYP3A Antibody |
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| P3ACON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Human CYP1A2 Antibody |
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| P1A2CON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Rat CYP2B1 Antibody |
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| P2B1PTCON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Rat CYP2C Antibody |
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| P2CCON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Rat CYP2D Antibody |
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| P2DCON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Human CYP2E1 Antibody |
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| P2E1PTCON | Detroit R&D | 100 uL | EUR 125 |
 Purified bovine Lactoferrin protein control for Western |
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| LTF13-C | Alpha Diagnostics | 100 ul | EUR 286 |
 for IHC) Mouse negative control sera (purified) for IHC |
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| NCM802M | Innovex | 7 ml | EUR 199 |
 Control/Blocking peptide for Ephrin-B2 antibody |
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| NIVE2B-C | Alpha Diagnostics | 100 ug | EUR 164 |
 Chicken Egg Ovalbumin protein control for Western |
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| OVA11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Positive Control for Anti-Rat MEH Antibody |
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| MEHCON | Detroit R&D | 100 uL | EUR 125 |
 Control Sections for FD NeuroSilver™ Kit |
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| PCS101 | FD Neurotechnologies | each | EUR 53.83 |
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Description: Best quality products |
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 Positive Control for Anti-Human CYP1B1 Antibody |
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| PH1B1CON | Detroit R&D | 100 uL | EUR 125 |
 Purified, Bovine S100 protein control for WB |
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| S1001-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified, Human S100 protein control for WB |
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| S1002-C | Alpha Diagnostics | 100 ul | EUR 286 |
) Control/Blocking peptide for Mouse Vimentin (Vim) |
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| VIM11-C | Alpha Diagnostics | 100 ug | EUR 164 |
 Control/Blocking peptide for Human WNT-1 |
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| WNT111-P | Alpha Diagnostics | 100 ug | EUR 457 |
) Control siRNA Vector (pGB-control) |
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| 9500C-20 | Biovision | EUR 338 | |
 Mouse Anti-Cardiolipin Ig's -ve control for ELISA |
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| 5502 | Alpha Diagnostics | 1 ml | EUR 225 |
 Human Apolipoprotein C-I protein control for WB |
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| APOC11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human Apolipoprotein C-II protein control for WB |
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| APOC22-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human Apolipoprotein C-III protein control for WB |
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| APOC32-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human plasma Apolipoprotein E protein control for WB |
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| APOE13-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human Plasma Apolipoprotein J protein control for WB |
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| APOJ13-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified Cholera Toxin protein control for Western Blot |
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| CTOX11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 protein control for Western) Chicken Egg Conalbumin (ovotransferrin) protein control for Western |
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| CECA15-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Chicken Egg white proteins total control for Western |
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| CEGW12-C | Alpha Diagnostics | 100 ul | EUR 286 |
 protein control for WB) Purified human Catalase (CATL) protein control for WB |
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| CATL11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Positive Control for Anti-Human Cytochrome b5 Antibody |
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| Cb5CON | Detroit R&D | 100 uL | EUR 125 |
 Chicken Egg yellow proteins total control for Western |
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| CEYP12-C | Alpha Diagnostics | 100 ul | EUR 286 |
 protein control for Western) Rabbit Beta Actin (muscle) protein control for Western |
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| ACTB15-C | Alpha Diagnostics | 100 ul | EUR 324 |
 Recombinant Beta Lactamase protein control for Western blot |
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| BLAC11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Chicken Serum Albumin protein control for Western blot |
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| ALBC15-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Serum Albumin protein control for WB) Monkey (Rhesus) Serum Albumin protein control for WB |
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| ALBMK21-C | Alpha Diagnostics | 100 ul | EUR 286 |
Monkey (Rhesus) Serum Albumin protein control for WB |
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| ALBMK22-C | Alpha Diagnostics | 100 ul | EUR 286 |
 protein control for Western) Chicken Ovomucoid (trypsin inhibitor) protein control for Western |
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| COVM13-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Control/Blocking peptide for Mouse Histone deacetylase 1 |
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| HDAC111-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Purified Human Neutrophil Elastase protein control for WB |
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| ESTE11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Positive Control for Anti-Rat CYP1A1/1A2 Antibody |
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| P1ACON | Detroit R&D | 100 uL | EUR 125 |
 Positive Control for Anti-Rat CHP2B1/2 Antibody |
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| P2B12PTCON | Detroit R&D | 100 uL | EUR 125 |
 Purified Lassa fever Nucleoprotein control for Western Blotting |
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| LFNP15-C-10 | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified Nipah virus Glycoprotein control for Western Blotting |
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| NIV11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified Nipah virus Nucleoprotein control for Western Blotting |
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| NIV21-C | Alpha Diagnostics | 100 ul | EUR 225 |
 Myoglobin, Human Cardiac, purified protein control for western |
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| MYG17-C | Alpha Diagnostics | 100 ul | EUR 286 |
 protein control for Western) Human Prothrombin (Factor II) protein control for Western |
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| PRTN11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 protein control for Western) Mouse Prothrombin (Factor II) protein control for Western |
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| PRTN13-C | Alpha Diagnostics | 100 ul | EUR 286 |
) Control sections for FD NeuroApop™ Kit (paraffin) |
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| PCS102-1 | FD Neurotechnologies | each | EUR 67.03 |
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Description: Best quality products |
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) Control sections for FD NeuroApop™ Kit (frozen) |
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| PCS102-2 | FD Neurotechnologies | each | EUR 67.12 |
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Description: Best quality products |
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 Human Pancreatic Amylase protein control for Western blot |
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| PAMY13-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human Salivary Amylase protein positive control for WB |
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| SAMY16-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified Human Survivin protein for WB +ve control |
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| SURV11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified, recombinant Human TACE control protein for WB |
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| TACE11-C | Alpha Diagnostics | 100 ul | EUR 286 |
Control sections for FD NeuroApop™ Kit (frozen) |
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| PCS102- | FD Neurotechnologies | each | EUR 73 |
 control for western blot) Recombinant Porcine reproductive and Respiratory syndrome virus 1 nuclear protein (PRRSV1-NP) control for western blot |
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| PRSNP11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 control for western blot) Recombinant Porcine reproductive and Respiratory syndrome virus 2 nuclear protein (PRRSV2 NP) control for western blot |
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| PRSNP21-C | Alpha Diagnostics | 100 ul | EUR 286 |
 control for western blot) Recombinant Porcine reproductive and Respiratory syndrome virus 1 nonstructural protein (PRRSV1-NSP) control for western blot |
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| PRSNSP11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 control for western blot) Recombinant Porcine reproductive and Respiratory syndrome virus 2 nonstructural protein (PRRSV2-NSP) control for western blot |
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| PRSNSP22-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Quality Control |
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| abx098966-1vial | Abbexa | 1 vial | EUR 300 |
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 pMD18- Control |
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| PVT10563 | Lifescience Market | 2 ug | EUR 266 |
New Mammalian Goal of Rapamycin (mTOR) Modulators Derived from Pure Product Databases and Marine Extracts by Utilizing Molecular Docking Methods.
Mammalian goal of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that capabilities as a grasp regulator of mobile enchancment and metabolism, in response to nutrient and hormonal stimuli.
mTOR capabilities in two distinct complexes-mTORC1 is delicate to rapamycin, whereas, mTORC2 is insensitive to this drug. Deregulation of mTOR’s enzymatic prepare has roles in most cancers, weight points, and ageing.
Rapamycin and its chemical derivatives are the solely remedy that inhibit the hyperactivity of mTOR, nonetheless pretty quite a few undesirable uncomfortable unwanted side effects have been described on account of its therapeutic use.
The purpose of this evaluation was to search out out new compounds of pure origin that can finish in remedy with fewer undesirable uncomfortable unwanted side effects. Now now we have now used computational methods (molecular docking and calculated ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) parameters) which have enabled the choice of candidate compounds, derived from marine pure merchandise, SuperNatural II, and ZINC pure merchandise, for inhibitors concentrating on, each, the ATP and the rapamycin binding websites of mTOR. Now now we have now confirmed experimental proof of the inhibitory prepare of 11 chosen compounds in opposition to mTOR.
Now now we have now furthermore found the inhibitory prepare of a mannequin new marine extract in opposition to this enzyme. The outcomes have been talked about concerning the need to search out out new molecules for therapeutic use, considerably in opposition to ageing, and with fewer undesirable uncomfortable unwanted side effects.
Molecular cloning and expression evaluation of three ThERFs concerned contained in the response to waterlogging stress of Taxodium ‘Zhongshanshan406’, and subcellular localization of the gene merchandise.
As a subfamily of the APETALA 2/ethylene response problem binding protein (AP2/EREBP) transcription concern superfamily, the ethylene response concern (ERF) is broadly concerned contained in the regulation of enchancment and response to completely different abiotic stresses in vegetation, and has been confirmed to be the principle transcription concern regulating transcription of the genes associated to hypoxia and waterlogging stress.
- On this evaluation, three ThERF genes, with crucial variations in expression profile in response to flooding stress, had been acknowledged from the transcriptomics data acquired from Taxodium hybrid ‘Zhongshanshan 406’ (T. mucronatum Tenore × T. distichum (L.) Wealthy) beneath waterlogging stress: ThERF15, ThERF39 and ThRAP2.3 (GenBank ID: KY463467, KY463468 and KY463470, respectively).
- Your complete-length cDNA of every of the three ERFs was obtained utilizing the RACE (fast amplification cDNA ends) methodology, and all three had been intron-free. Quite a few protein sequence alignments indicated that ThERF15, ThERF39 and ThRAP2.Three proteins all had just one AP2-ERF area and belonged to the ERF subfamily.
- A transient gene expression assay demonstrated that ThERF15, ThERF39 and ThRAP2.Three had been all localized to the nucleus. Exact-time quantitative PCR (qPCR) revealed that the expression of ThERF15, ThERF39 and ThRAP2.Three exhibited crucial variations, in distinction with the administration, in response to 2 ranges of flooding treatment (half-flooding or total-submergence) of ‘Zhongshanshan 406’.
- Quantification of ethylene focus revealed that ethylene was additional related to the extent of expression than the interval of flooding treatment. Primarily based completely on the experimental outcomes above, ThERF15, ThERF39 and ThRAP2.Three had been acknowledged as being associated to the regulation of downstream flooding- responsive gene expression in ‘Zhongshanshan 406’. ThRAP2.Three is sort of really to be a key downstream-response ERF gene to answer the output of the ethylene sign generated by flooding stress
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