Dopamine oxidation Merchandise as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Sickness.
The preferential degeneration of dopaminergic neurons inside the substantia nigra pars compacta is accountable for the motor impairment associated to Parkinson’s sickness. Dopamine is a extraordinarily reactive molecule, which is often saved inside synaptic vesicles the place it is stabilized by the ambient low pH.
Nonetheless, free cytosolic dopamine can auto-oxidize, producing reactive oxygen species, and end result within the formation of toxic quinones. Throughout the present work, we’ve got now analyzed the mechanisms by the use of which the dysfunction of dopamine homeostasis might induce cell toxicity, by focusing particularly on the hurt induced by dopamine oxidation merchandise on the mitochondrial diploma.
Our outcomes level out that dopamine derivatives impact mitochondrial morphology and induce mitochondrial membrane depolarization, leading to a reduction of ATP synthesis. Moreover, our outcomes counsel that opening of the mitochondrial transition pore induced by dopamine-derived quinones may contribute to the exact Parkinson’s disease-associated vulnerability of dopamine containing neurons.
 Goat polyclonal antibody for Epstein-Barr virus |
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| 277 | Virostat | 1 ml | EUR 300.13 |
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Description: This is Biotin conjugated goat polyclonal antibody against Epstein-Barr virus EBNA-1 for WB, ELISA. |
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Goat polyclonal antibody for Epstein-Barr virus |
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| 3714 | Virostat | 1 ml | EUR 321.88 |
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Description: This is HRP conjugated goat polyclonal antibody against Epstein-Barr virus p18 for WB, ELISA. |
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 Mouse antibody for Epstein-Barr virus Bcl-2 |
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| 235 | Virostat | 100 ug | EUR 321.88 |
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Description: This is purified Mouse monoclonal antibody against Epstein-Barr virus Bcl-2 for WB, ELISA. |
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 Mouse antibody for Epstein-Barr virus EA-D |
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| 261 | Virostat | 100 ug | EUR 321.88 |
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Description: This is purified Mouse monoclonal antibody against Epstein-Barr virus EA-D for WB, ELISA. |
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 Mouse antibody for Epstein-Barr virus EBNA-1 |
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| 212 | Virostat | 100 ug | EUR 321.88 |
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Description: This is purified Mouse monoclonal antibody against Epstein-Barr virus EBNA-1 for WB, ELISA. |
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 Strain:B95-8,External Run Control-Medium(6X1mL)) NATtrol Epstein Barr Virus (EBV) Strain:B95-8,External Run Control-Medium(6X1mL) |
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| NATEBV-ERCM | Zeptometrix | 6X1mL | EUR 391.12 |
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Description: Please contact Gentaur in order to receive the datasheet of the product. |
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) Epstein-Barr virus Epstein-Barr nuclear antigen 3 (EBNA3) |
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| 1-CSB-EP319032EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 3 (EBNA3),partial expressed in E.coli |
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) Epstein-Barr virus Epstein-Barr nuclear antigen 1 (EBNA1) |
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| 1-CSB-EP365878EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 1(EBNA1),partial expressed in E.coli |
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) Epstein-Barr virus Epstein-Barr nuclear antigen 2 (EBNA2) |
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| 1-CSB-YP718162EEZ(A4) | Cusabio |
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Description: Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2(EBNA2),partial expressed in Yeast |
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 Mouse antibody for Epstein-Barr virus gp 250/350 |
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| 221 | Virostat | 100 ug | EUR 321.88 |
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Description: This is purified Mouse monoclonal antibody against Epstein-Barr virus gp 250/350 for WB, ELISA. |
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 Mouse antibody for Epstein-Barr virus Bam H1 Z |
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| 256 | Virostat | 100 ug | EUR 321.88 |
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Description: This is purified Mouse monoclonal antibody against Epstein-Barr virus Bam H1 Z for WB, ELISA. |
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 Strain: B95-8, External Run Control-Low (6X1mL)) NATtrol Epstein Barr Virus (EBV) Strain: B95-8, External Run Control-Low (6X1mL) |
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| NATEBV-ERCL | Zeptometrix | 6X1mL | EUR 329.76 |
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Description: Please contact Gentaur in order to receive the datasheet of the product. |
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 Antibody) Epstein-Barr Virus (EBV) Antibody |
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| abx021696-1mg | Abbexa | 1 mg | EUR 1156 |
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Epstein-Barr Virus (EBV) Antibody |
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| abx021699-1mg | Abbexa | 1 mg | EUR 1156 |
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Epstein-Barr Virus (EBV) Antibody |
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| abx021702-1mg | Abbexa | 1 mg | EUR 1156 |
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 Epstein-Barr Virus Nuclear Antigen |
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| abx670096-01mg | Abbexa | 0.1 mg | EUR 1191 |
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 Anti-Epstein Barr Virus antibody |
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| STJ16100364 | St John's Laboratory | 1 mL | EUR 754 |
antibody (IgG)) ELISA kit for Human epstein-barr virus (EBv)antibody (IgG) |
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| EK0203 | SAB | 96 tests | EUR 830 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human epstein-barr virus (EBv)antibody (IgG) in samples from serum, plasma, tissue homogenates and other biological fluids. |
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 antibody (IgM)) ELISA kit for Human epstein-barr virus (Ebv) antibody (IgM) |
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| EK0204 | SAB | 96 tests | EUR 830 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human epstein-barr virus (Ebv) antibody (IgM) in samples from serum, plasma, tissue homogenates and other biological fluids. |
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) Epstein-Barr virus Glycoprotein BDLF3 (BDLF3) |
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| 1-CSB-EP365881EFA1 | Cusabio |
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Description: Recombinant Epstein-Barr virus Glycoprotein BDLF3(BDLF3),partial expressed in E.coli |
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 Antibody (FITC)) Epstein-Barr Virus (EBV) Antibody (FITC) |
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| abx021698-100ug | Abbexa | 100 ug | EUR 732 |
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 Anti-Human Epstein-Barr Virus antibody |
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| STJ16100457 | St John's Laboratory | 1 mL | EUR 240 |
 Anti-Epstein-Barr virus LMP antibody |
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| STJ16100853 | St John's Laboratory | 1 mL | EUR 964 |
) ELISA kit for Mouse EBI3 (Epstein Barr Virus Induced Protein 3) |
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| ELK6316 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Epstein Barr Virus Induced Protein 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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 Purified Nipah virus Glycoprotein control for Western Blotting |
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| NIV11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Purified Nipah virus Nucleoprotein control for Western Blotting |
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| NIV21-C | Alpha Diagnostics | 100 ul | EUR 225 |
 p18) Recombinant Epstein-Barr Virus (HHV-4) p18 |
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| 7-07795 | CHI Scientific | 100µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) p18 |
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| 7-07796 | CHI Scientific | 500µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) p18 |
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| 7-07797 | CHI Scientific | 1000µg | Ask for price |
 p23) Recombinant Epstein-Barr Virus (HHV-4) p23 |
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| 7-07804 | CHI Scientific | 100µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) p23 |
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| 7-07805 | CHI Scientific | 500µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) p23 |
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| 7-07806 | CHI Scientific | 1000µg | Ask for price |
 Recombinant Human Epstein Barr Virus Induced 3 |
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| 7-00256 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Epstein Barr Virus Induced 3 |
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| 7-00257 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Epstein Barr Virus Induced 3 |
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| 7-00258 | CHI Scientific | 1mg | Ask for price |
 Recombinant Mouse Epstein Barr Virus Induced 3 |
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| 7-00262 | CHI Scientific | 2µg | Ask for price |
Recombinant Mouse Epstein Barr Virus Induced 3 |
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| 7-00263 | CHI Scientific | 10µg | Ask for price |
Recombinant Mouse Epstein Barr Virus Induced 3 |
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| 7-00264 | CHI Scientific | 1mg | Ask for price |
) Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1) |
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| 1-CSB-EP314488EFC | Cusabio |
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Description: Recombinant Epstein-Barr virus Apoptosis regulator BHRF1(BHRF1),partial expressed in E.coli |
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) Epstein-Barr virus Envelope glycoprotein B (gB) |
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| 1-CSB-EP355975EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Envelope glycoprotein B(gB),partial expressed in E.coli |
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) Epstein-Barr virus Envelope glycoprotein L (gL) |
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| 1-CSB-EP355982EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Envelope glycoprotein L(gL) expressed in E.coli |
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) Epstein-Barr virus Envelope glycoprotein GP350 (BLLF1) |
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| 1-CSB-EP360986EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Envelope glycoprotein GP350(BLLF1),partial expressed in E.coli |
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) Epstein-Barr virus Envelope glycoprotein H (gH) |
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| 1-CSB-EP365883EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Envelope glycoprotein H(gH),partial expressed in E.coli |
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 Recombinant Epstein–Barr Virus P23, GST-tagged |
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| DAG511 | Creative Diagnostics | 1mg | EUR 1112 |
 Epstein Barr Virus NA1 IgA ELISA Kit |
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| DEIA1030 | Creative Diagnostics | 96T | EUR 556 |
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Description: For the qualitative determination of IgA class antibodies against Epstein Barr Virus in Human serum or plasma. It is intended for diagnosing and monitoring of patients related to infection by Epstein Barr Virus. |
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 Epstein Barr Virus Zta IgA ELISA Kit |
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| DEIA1034 | Creative Diagnostics | 96T | EUR 556 |
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Description: For the qualitative determination of IgA class antibodies against Epstein Barr Virus in Human serum or plasma. It is intended for diagnosing and monitoring of patients related to infection by Epstein Barr Virus. |
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 Epstein-Barr virus EBNA-1 recombinant antigen |
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| 8916 | Virostat | 100 ug | EUR 615.5 |
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Description: This is Epstein-Barr virus EBNA-1 recombinant antigen for ELISA,WB. |
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 ELISA Kit) Human Epstein-Barr Virus (EBV) ELISA Kit |
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| abx054176-96tests | Abbexa | 96 tests | EUR 668 |
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 p18 Protein) Epstein-Barr Virus (HHV-4) p18 Protein |
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| 20-abx260115 | Abbexa |
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 p23 Protein) Epstein-Barr Virus (HHV-4) p23 Protein |
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| 20-abx260116 | Abbexa |
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 EBNA1 Protein) Epstein-Barr Virus (HHV-4) EBNA1 Protein |
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| 20-abx260340 | Abbexa |
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Epstein-Barr Virus (HHV-4) p18 Protein |
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| 20-abx260341 | Abbexa |
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 Antibody) Epstein-Barr Virus Induced 3 (EBI3) Antibody |
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| abx432634-200ul | Abbexa | 200 ul | EUR 286 |
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Epstein-Barr Virus Induced 3 (EBI3) Antibody |
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| abx232615-100ug | Abbexa | 100 ug | EUR 551 |
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 Camelpox virus H3L/p35 protein control for western blot |
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| CPOX11-C | Alpha Diagnostics | 100 ul | EUR 286 |
) pGreenPuro Scramble Hairpin Control - Virus (for shRNAs and miRZips) |
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| MZIP000-VA-1 | SBI | >1 x 10^6 IFUs | EUR 716 |
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 Capsid Protein control for Western Blotting) Mayaro virus (MAYV) Capsid Protein control for Western Blotting |
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| MAYV31-C | Alpha Diagnostics | 100 ul | EUR 286 |
 nsP1 protein control for Western Blotting) Mayaro virus (MAYV) nsP1 protein control for Western Blotting |
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| MAYV41-C | Alpha Diagnostics | 100 ul | EUR 286 |
 6K Protein control for Western Blotting) Mayaro virus (MAYV) 6K Protein control for Western Blotting |
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| MAYV51-C | Alpha Diagnostics | 100 ug | EUR 286 |
 E3 protein control for Western Blotting) Mayaro virus (MAYV) E3 protein control for Western Blotting |
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| MAYV61-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Control/Blocking peptide for Tobacco Mosaic Virus Movement Protein |
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| TMVMP11-P | Alpha Diagnostics | 100 ug | EUR 164 |
 control for Western blot) Zika Virus prM Protein (African) control for Western blot |
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| ZPRM11-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Core Panel Multi-Tumor control slides |
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| TS900 | Innovex | Set of 5 | EUR 218 |
Core Panel Multi-Tumor control slides |
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| TS900-25 | Innovex | Set of 25 | EUR 485 |
 Breast Panel Multi-Tumor control slides |
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| TS901 | Innovex | Set of 5 | EUR 218 |
Breast Panel Multi-Tumor control slides |
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| TS901-25 | Innovex | Set of 25 | EUR 485 |
 (isotype control)) Goat IgG (-ve control for flow cytometry) (isotype control) |
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| 20011-100 | Alpha Diagnostics | 100 test | EUR 103 |
 BSA Control for Age-BSA |
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| 2221-BSA | Biovision | EUR 175 | |
 BSA Control for AGE-BSA |
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| 35R-AA007 | Fitzgerald | 10 mg | EUR 224 |
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Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007 |
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 AAV1-GFP Control Virus |
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| AAV-301 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: GFP control virus of AAV serotype 1. |
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 AAV2-GFP Control Virus |
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| AAV-302 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: GFP control virus of AAV serotype 2. |
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 AAV3-GFP Control Virus |
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| AAV-303 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: GFP control virus of AAV serotype 3. |
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 AAV4-GFP Control Virus |
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| AAV-304 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: GFP control virus of AAV serotype 4. |
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 AAV5-GFP Control Virus |
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| AAV-305 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: GFP control virus of AAV serotype 5. |
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 AAV6-GFP Control Virus |
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| AAV-306 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: GFP control virus of AAV serotype 6. |
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 AAV2-Cre Control Virus |
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| AAV-310 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Cre control virus of AAV serotype 2. |
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 AAV1-Cre Control Virus |
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| AAV-311 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Cre control virus of AAV serotype 1. |
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 AAV3-Cre Control Virus |
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| AAV-313 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Cre control virus of AAV serotype 3. |
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 AAV4-Cre Control Virus |
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| AAV-314 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Cre control virus of AAV serotype 4. |
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 AAV5-Cre Control Virus |
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| AAV-315 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Cre control virus of AAV serotype 5. |
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 AAV6-Cre Control Virus |
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| AAV-316 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Cre control virus of AAV serotype 6. |
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 AAV2-Luc Control Virus |
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| AAV-320 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Luciferase control virus of AAV serotype 2. |
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 AAV1-Luc Control Virus |
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| AAV-321 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Luciferase control virus of AAV serotype 1. |
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 AAV3-Luc Control Virus |
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| AAV-323 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Luciferase control virus of AAV serotype 3. |
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 AAV4-Luc Control Virus |
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| AAV-324 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Luciferase control virus of AAV serotype 4. |
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 AAV5-Luc Control Virus |
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| AAV-325 | Cell Biolabs | 50 ?L | EUR 1018 |
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Description: Luciferase control virus of AAV serotype 5. |
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Inhibition of superior glycation end merchandise by isoferulic acid and its free radical scavenging functionality: An in vitro and molecular docking study.
Non-enzymatic glycation and Oxidation of some vital natural macromolecules are paramount inside the pathogenesis of various sicknesses along with diabetes and atherosclerosis.
- Hyperglycemia performs a key perform inside the pathological technique of diabetic issues by progressive accumulation of superior glycation end merchandise (AGEs) in physique tissues. Formation of AGEs on account of protein glycation is adopted by an elevated free radical train that furthermore contributes in course of the bio-macromolecular hurt.
- The present study aimed to guage the free radical scavenging and antiglycation functionality of isoferulic acid (IFA). The free radical scavenging train of IFA was measured using DPPH, FRAP, and metal chelating assays. IFA confirmed environment friendly reducing vitality, free radical scavenging train and metal chelation train in focus dependent technique.
- The antiglycation train of IFA was studied using quite a few spectroscopic strategies. The obtained outcomes had been validated with free amino, sulfhydryl group, carbonyl content material materials and AGEs formation. Secondary structural alterations had been monitored using spherical dichroism, morphology of aggregates was analyzed using transmission electron microscopy.
- Molecular docking reveals the doable binding location of IFA with inside the sub-domain IIA of human serum albumin (HSA).
LC/QTOF/MS/MS characterization, molecular docking and in silico toxicity prediction analysis on degradation products of anagliptin.
Pharmaceutical medicine are potential molecules with explicit natural train. Nonetheless, long-term use of these chemical molecules can impact the human physiological system because of their elevated ranges inside the human physique. Resulting from this truth, identification and development elucidation of impurities or degradation merchandise must be thought of in order to ensure drug safety.
The present study assessed the degradation behaviour of dipeptidyl peptidase-4 (DPP-4) inhibitor anagliptin under completely completely different stress conditions as per ICH suggestions Q1A (R2) adopted by elucidation of the development of degradation merchandise. All the stress samples had been analysed by using UPLC/PDA.
The superior separation of drug from its degradation merchandise was attained with time programmed gradient elution on BEH C18 (100 mm × 2.1 mm, 1.7 μm) column using 10 mM ammonium formate (aqueous) and acetonitrile (pure) as a result of the cell half components.
All the degradation merchandise of anagliptin had been characterised using LC/QTOF/MS/MS. In addition to, the train and toxicity of degradation merchandise had been determined by the use of molecular docking and in silico toxicity prediction analysis, respectively. The developed UPLC/PDA approach was validated as per ICH suggestions on the subject of specificity, accuracy, precision, linearity and robustnes
Molecular Distributions of Soluble Oxidation Merchandise from Coals Characterised by Mass Spectrometers.
Oxidation of three coals with rank from lignite to anthracite in NaOCl aqueous reply was investigated on this study. The oxidation merchandise had been characterised by using gasoline chromatography/mass spectrometry and direct analysis in real-time mass spectrometry.
The outcomes confirmed that almost all of pure compounds in coals had been reworked into water-soluble species under delicate conditions, even the anthracite. Benzene polycarboxylic acids (BPCAs) and chloro-substituted alkanoic acids (CSAAs) had been most important merchandise from the reactions.
The merchandise from lower rank coals embody considerable CSAAs and most merchandise from extreme rank coals are BPCAs. As coal rank will enhance, the yield of BPCAs with additional carboxylic groups will enhance.
Product not found